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Energetics of Protein-Nucleic Acid Interactions
MB&B525 SP

This is a half-semester course, offered in the second half of the spring semester. Students have five days after the first day of class to add this course. This course focuses on the thermodynamics of binding proteins, drugs and other ligands to nucleic acids. Topics include cooperativity in binding of proteins to DNA, statistical thermodynamics of molecular switches in gene regulation, energetic linkages in binding of ligands to nucleic acids. The relationships between thermodynamics of protein-nucleic acid interactions and molecular mechanisms of gene expression are emphasized.

MAJOR READINGS

Selected papers from scientific journals.

EXAMINATIONS AND ASSIGNMENTS

Homework assignments and final exam.

ADDITIONAL REQUIREMENTS and/or COMMENTS

Unless preregistered students attend the first class meeting or communicate directly with the instructor prior to the first class, they will be dropped from the class list. NOTE: Students must still submit a completed Drop/Add form to the Registrar's Office.

COURSE FORMAT: Lecture

REGISTRATION INFORMATION

Level: GRAD    Credit: .5    Gen Ed Area Dept: NONE    Grading Mode: Student Option   

Prerequisites: NONE

Last Updated on MAR-24-2000

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