MB&B539

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MB&B539

Gene Regulation MB&B539 FA

Next Offered in 9899 FA

This is a 1/2 semester course (Tuesday, September 13, thru Tuesday October 25). Discussion of topics in the regulation of eukaryotic gene expression such as: Transcription factors and their mode of action; enhancers; silencers; locus control region and insulators; and the role of nucleosome positioning and chromatin structure. In addition, several illuminating systems such as the response to steroid hormones or heat shock; the control of yeast mating type; muscle differentiation and MyoD; and homeoproteins in development will be examined. Control of gene expression by RNA processing, stability or translation will be briefly considered. Emphasis throughout the course will be placed on the experimental methods that have given us our current understanding of the regulation of gene expression.

MAJOR READINGS

Research papers from the primary literature.

EXAMINATIONS AND ASSIGNMENTS

Presenting papers in class, ten minute weekly quizzes and a short written summary at the end of the course of each participant's view of what significant generalizations emerged from the course. The instructor will provide some references for each topic, and some may be contributed by the student presenting the topic.

ADDITIONAL REQUIREMENTS and/or COMMENTS

Undergraduates who have taken MB&B208 and appear capable of benefiting from the course should consult the instructor prior to enrolling in the course.

COURSE FORMAT: Discussion Seminar

REGISTRATION INFORMATION

Level: GR Credit: 0.50

Prerequisites: MB&B208

Last Updated on MAR-10-1997

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