Topics in Nucleic Acid Structure MB&B520 SP

This course focuses on the principles of nucleic acid structure. The scope of this course is to go beyond the more common DNA structures such as B-DNA, A-DNA helical structures and concentrate more on other DNA structural motifs like triplex DNA and quadruplex DNA. Physical characterization of these structures as well as the functional implication of these structures (in terms of DNA replication, transcription, telomeres, etc.) will be discussed extensively. Discussion will also center on the forces that stabilize these structures, such as H-bonding and stacking interactions. The course will also cover other important DNA structural motifs such as curved or bent DNA as found in A-tracts and the relevance of these structures in promoter recognition and gene expression. Important RNA structures, such as bulges, loops, hairpins, etc., relevant for recognition will also be discussed. Prerequisites include undergraduate courses in both molecular biology and biochemistry. This is a half semester course and will be offered the first half of the spring semester.

MAJOR READINGS

EXAMINATIONS AND ASSIGNMENTS

ADDITIONAL REQUIREMENTS and/or COMMENTS

COURSE FORMAT: Lecture

REGISTRATION INFORMATION

Level: GR Credit: 0.50

Prerequisites: None

Section 01

Mukerji, I

Times: M...... 1:10PM;

Grading Mode: Mixed

Registration Preference (1 high to 6 low, 0=Excluded) Sr: 1, Jr: 2, So: 0, Fr: 0

Major Preference Given

Last Updated on MAR-10-1997