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Academic Year 2005/2006


Evolutionary and Ecological Bioinformatics
BIOL 327 SP

Crosslistings:
COMP 327
BIOL 527
COMP 527

Bioinformatic analysis of gene sequences and gene expression patterns has added enormously to our understanding of ecology and evolution. For example, through bioinformatic analysis of gene sequences, we can now reconstruct the evolutionary history of physiology even though no traces of physiology exist in the fossil record. We can determine the adaptive history of one gene and all the gene's descendants. We can now construct the evolutionary tree of all of life. Bioinformatics is particularly promising for analysis of the ecology and biodiversity of microbial communities, since well over 99% of microorganisms cannot be cultured--our only knowledge of these organisms is through analysis of their gene sequences and gene expression patterns. For example, even when we cannot culture most of a microbial community, we can determine which metabolic pathways are of greatest significance through analysis of community-level gene expression. All these research programs are made accessible not only by breakthroughs in molecular technology, but also by innovation in the design of computer algorithms. This course, team-taught by an evolutionary biologist and a computer scientist, will present how bioinformatics is revolutionizing evolutionary and ecological investigation, and will present the design and construction of bioinformatic computer algorithms underlying the revolution in biology.

MAJOR READINGS

To be announced

EXAMINATIONS AND ASSIGNMENTS

Two mid-term exams, a final exam, homework and a project in evolutionary or ecological bioinformatics.

COURSE FORMAT: Lecture

REGISTRATION INFORMATION

Level: UGRD    Credit: 1    Gen Ed Area Dept: NONE    Grading Mode: Student Option   

Prerequisites: [MB&B205 or BIOL205] OR [BIOL206 or MB&B206] OR BIOL207 OR COMP212 OR [COMP312 or COMP510] OR [MB&B225 or BIOL225] OR [MB&B181 or BIOL181] OR [MB&B195 or BIOL195] OR [BIOL182 or MB&B182] Links to Web Resources For This Course.

Last Updated on MAR-30-2006


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