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Academic Year 2003/2004

Molecular Processes in Post-Transcriptional Regulation of Gene Activity
MB&B 524 SP

This course will examine multiple processes through which the primary information derived from DNA is regulated and utilized by cells. Included will be topics such as RNA processing, editing, splicing, transport, activation, translation and degradation. The regulation of such post-transcriptional processes is critically important for cellular maintenance and activity; and alterations of them provides the bases of action for certain hormones and viruses. The influence of these processes on cell growth-division, cellular differentiation, normal embryonic development and carcinogenesis will be a major consideration. Enzymatically active RNAs (ribozymes) will be considered within the evolutionary model that hypothsizes a prior "RNA-based World".

MAJOR READINGS

Readings will be of articles from such journals as; Cell, Nature, Science, Genes & Development, Journal of Biochemistry. And from reviews in TIBS, and Genetics.

EXAMINATIONS AND ASSIGNMENTS

The course will have a final (take-home) exam and either a written assignment or a mid-term (take-home) exam.

ADDITIONAL REQUIREMENTS and/or COMMENTS

Prerequisite MB&B208 or permission of instructor. Unless preregistered students attend the first class meeting or communicate directly with the instructor prior to the first class, they will be dropped from the class list. NOTE: Students must still submit a completed Drop/Add form to the Registrar's Office.

COURSE FORMAT: Lecture

REGISTRATION INFORMATION

Level: GRAD    Credit: 1    Gen Ed Area Dept: NONE    Grading Mode: Graded   

Prerequisites: MB&B208 Links to Web Resources For This Course.

Last Updated on MAR-19-2004

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