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Academic Year 2000/2001


Topics in Nucleic Acid Structure
MB&B 520 SP

This course focuses on the principles of nucleic acid structure. The scope of this course is to go beyond the common DNA structures such as B-DNA and A-DNA helical structures. The course will concentrate on other DNA structural motifs like branched DNA, supercoiled DNA, triplex DNA and quadruplex DNA. Physical characterization of these structures as well as the functional implication of these structures (in terms of DNA replication, transcription, telomeres, etc.) will be discussed extensively. Discussion will also center on the forces that stabilize these structures, such as H-bonding and stacking interactions. The course will also cover other important DNA structural motifs such as curved or bent DNA as found in A-tracts and the relevance of t hese structures in promoter recognition and gene expression. Important RNA structures, such as ribozymes and pseudoknots will also be discussed. Prerequisites include undergraduate courses in both molecular biology and biochemistry. This is a half semes ter course and will be offered the first half of the spring semester.

MAJOR READINGS

Handouts from current literature.
R. Sinden, DNA STRUCTURE AND FUNCTION

EXAMINATIONS AND ASSIGNMENTS

One paper and one oral presentation.

ADDITIONAL REQUIREMENTS and/or COMMENTS

Students must withdraw from this class by Friday, March 5.

Unless preregistered students attend the first class meeting or communicate directly with the instructor prior to the first class, they will be dropped from the class list. NOTE: Students must still submit a completed Drop/Add form to the Registrar's Office.

COURSE FORMAT: Lecture

REGISTRATION INFORMATION

Level: GRAD    Credit: .5    Gen Ed Area Dept: NONE    Grading Mode: Student Option   

Prerequisites: NONE

SECTION 01

Instructor(s): Mukerji,Ishita   
Times: ..T.T.. 01:10PM-02:30PM;     Location: TBA
Reserved Seats:    (Total Limit: UNL)
SR. major:    Jr. major:
SR. non-major:    Jr. non-major:    SO: X   FR: X

Special Attributes:
Links to Web Resources For This Course.

Last Updated on MAR-26-2001


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