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This course focuses on the principles of nucleic acid structure. The scope of this course is to go beyond the common DNA structures such as B-DNA and A-DNA helical structures. The course will concentrate on other DNA structural motifs like branched DNA, supercoiled DNA, triplex DNA and quadruplex DNA. Physical characterization of these structures as well as the functional implication of these structures (in terms of DNA replication, transcription, telomeres, etc.) will be discussed extensively. Discussion will also center on the forces that stabilize these structures, such as H-bonding and stacking interactions. The course will also cover other important DNA structural motifs such as curved or bent DNA as found in A-tracts and the relevance of t hese structures in promoter recognition and gene expression. Important RNA structures, such as ribozymes and pseudoknots will also be discussed. Prerequisites include undergraduate courses in both molecular biology and biochemistry. This is a half semes ter course and will be offered the first half of the spring semester.
Unless preregistered students attend the first class meeting or communicate directly with the instructor prior to the first class, they will be dropped from the class list. NOTE: Students must still submit a completed Drop/Add form to the Registrar's Office.
COURSE FORMAT: Lecture
Level: GRAD Credit: .5 Gen Ed Area Dept: NONE Grading Mode: Student Option
Prerequisites: NONE
Last Updated on MAR-26-2001
Copyright Wesleyan University, Middletown, Connecticut, 06459